Vitamin B6, but not vitamin B12, is associated with increased risk of hip fracture during extended follow-up, according to a study published online June 2 in the Journal of Bone and Mineral Research.
Maria Garcia Lopez, M.D., from the University Hospital in Oslo, Norway, and colleagues conducted a secondary analysis of combined data from two large randomized controlled trials to examine the effect of an intervention with B-vitamins on the risk of hip fracture. The intervention consisted of a daily capsule of folic acid plus vitamin B12 and vitamin B6, folic acid plus vitamin B12, folic acid plus vitamin B6, or placebo.