Use of platelet-rich plasma had no evident effect on patients undergoing total knee arthroplasty, according to study results. Researchers randomly assigned 40 patients who were scheduled to undergo primary unilateral total knee arthroplasty (TKA) to be treated with platelet-rich plasma (PRP) or to a control group. Patients' hemoglobin (Hb) and hematocrit levels were documented before surgery and again on days 1, 7, 14 and 28 postoperatively, and estimated blood loss was calculated. The researchers also recorded and assessed the patients' C-reactive protein (CRP) levels, range of motion, pain levels, knee extension muscle strength, knee swelling, circumference differences, Knee Society Knee Score, Knee Society Functional Score and KOOS at various time points throughout the study.